Cryoablation is a freezing technique similar to cold cautery. Where cold cautery is only used to treat skin tissue, cryoablation is used to more widely to treat various tissue types. The treatment can be precisely applied and leaves less scarring than traditional surgery. The cold deadens tiny nerve endings so there may be less pain as well.

Both radiofrequency ablation and cryoablation have been used successfully in treating kidney tumours (See Kidney Treatment).