4. Folliculin-associated signalling pathways

The following interactive figure illustrates the relationship between Folliculin and a number of different signalling pathways, which are discussed in more detail within this section.

Please click on the figure below for more information regarding each pathway. It is also possible to click ‘Expand’ for a moveable pop-up box detailing the phosphorylation events associated with Folliculin.

 

Lim et al., 2012 Succinate dehydrogenase Fumarate hydratase Baba et al., 2008 Hypoxia-inducible factor prolyl hydroxylase Hasumi et al., 2009 Hasumi et al., 2009 Preston et al., 2011 Chen et al., 2008 Hasumi et al., 2009 Baba et al., 2006 Takagi et al., 2008 Peña-Llopis et al., 2011 Baba et al., 2006 Hasumi et al., 2008 Klomp et al., 2010 Hong et al., 2010b Cash et al., 2011 Hong et al., 2010a Singh et al., 2006 5'-AMP-activated protein kinase Folliculin-interacting protein 1 Transcription factor E3 STAT signalling pathway TGF-beta signalling pathway Von Hippel-Lindau disease protein Hypoxia-inducible factor 1-alpha Hypoxia-inducible factor 2-alpha Tuberous sclerosis complex protein 1 / Hamartin Tuberous sclerosis complex protein 2 / Tuberin Phosphatase and tensin homolog Mammalian target of rapamycin complex 2 Serine/threonine-protein kinase LKB1 Serine/threonine-protein kinase Akt MAPK/ERK signalling pathway Phosphatidylinositol 3-kinase signalling pathway Hepatocyte growth factor receptor/Tyrosine-protein kinase Met Insulin receptor Epidermal growth factor receptor Folliculin-interacting protein 2 Folliculin / BHD syndrome protein Hudon et al., 2010 Baba et al., 2008 Komori et al., 2009 Lim et al., 2012 Cash et al., 2011 Takagi et al., 2008 GTP-binding protein Rheb Mammalian target of rapamycin complex 1 Hartman et al., 2009 Baba et al., 2008 Hudon et al., 2010 Folliculin / BHD syndrome protein 5'-AMP-activated protein kinase Expand Mammalian target of rapamycin complex 1 Baba et al., 2006 Yu et al., 2011 Piao et al., 2009 Baba et al., 2006 Yu et al., 2011 Baba et al., 2006 Lim et al., 2012 Wang et al., 2010 Takagi et al., 2008 Mammalian target of rapamycin complex 1 5'-AMP-activated protein kinase Folliculin-interacting protein 1 Folliculin-interacting protein 2 Folliculin / BHD syndrome protein Close

① Singh et al., 2006; ② Baba et al., 2006; ③ Baba et al., 2008; ④ Hasumi et al., 2008; ⑤ Takagi et al., 2008; ⑥ Chen et al., 2008; ⑦ Komori et al., 2009; ⑧ Hartman et al., 2009; ⑨ Hasumi et al., 2009; ⑩ Piao et al., 2009; ⑪ Wang et al., 2010; ⑫ Hudon et al., 2010; ⑬ Hong et al., 2010a; ⑭ Klomp et al., 2010; ⑮ Hong et al., 2010b; ⑯ Preston et al., 2011; ⑰ Cash et al., 2011; ⑱ Yu et al., 2011; ⑲ Peña-Llopis et al., 2011; ⑳ Lim et al., 2012

 

For more information, please click the links below:

5. Model organisms for studying BHD syndrome  →
← 3. Folliculin and its interacting partners

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