4. Folliculin-associated signalling pathways

Last reviewed – May 2013

Singh et al., 2006	Baba et al., 2006	Baba et al., 2008	Hasumi et al., 2008
Dephoure et al., 2008	Takagi et al., 2008	Chen et al., 2008	Komori et al., 2009
Hartman et al., 2009	Gauci et al., 2009	Hasumi et al., 2009	Piao et al., 2009
Wang et al., 2010	Hudon et al., 2010	Hong et al., 2010a	Behrends et al., 2010
Klomp et al., 2010	Hong et al., 2010b	Preston et al., 2011	Danielsen et al., 2011
Cash et al., 2011	Yu et al., 2011	Peña-Llopis et al., 2011	Wagner et al., 2011
Dodding et al., 2011	Lim et al., 2012	Furuya et al., 2012	Park et al., 2012
Baba et al., 2012	Nookala et al., 2012	Nahorski et al., 2012	Gaur et al., 2012
Medvetz et al., 2012	Hasumi et al., 2012	Reiman et al., 2012	Sano et al., 2012
Pimenta et al., 2012	Nishii et al., 2012	Pradella et al., 2013	Lu et al., 2013
Kawaii et al., 2013	Gharbi et al., 2013

The interactive diagram above illustrates the relationship between Folliculin (FLCN) and a number of proteins and signalling pathways, which are discussed in more detail below. In particular, the diagram highlights those factors that are currently thought to be directly linked to FLCN, while related pathways which provide context for these associations are faded.

Please click on each protein or pathway for more information. To view the pop-up boxes, click ‘Expand’ to see 1) the post-translational modifications associated with FLCN and 2) its C-terminal structure and interactome .

For more information, please click the links below:

• mTOR signalling
  

• Raf-MEK-Erk signalling
  

• JAK/STAT signalling
  

• HIF signalling
  

• TGF-β signalling and general transcriptional control