van Slegtenhorst et al. (2007) identified the S. pombe FLCN homologue called LST7, and used homologous recombination to generate a novel deletion strain. LST7 only has homology with the N-terminal region of the vertebrate protein, but these experiments suggest that yeast FLCN is important for amino acid homeostasis, and potentially activates the mTOR homologue Tor2.
