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Birt-Hogg-Dubé Syndrome
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6. Future Work
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← 5. Model organisms for studying BHD syndrome
For Researchers
What is BHD?
1. Clinical manifestations of BHD syndrome
Fibrofolliculomas (benign skin tumours)
Pulmonary cysts and pneumothorax
Renal cell carcinoma (Kidney Cancer)
Other clinical manifestations
2. Folliculin gene
Identification of the FLCN gene
Mutations in FLCN: Knudson’s two-hit hypothesis
FLCN mutation databases
3. Folliculin and its interacting partners
Folliculin protein
Folliculin-binding proteins
Cellular localisation
4. Folliculin-associated signalling pathways
mTOR signalling
Raf-MEK-Erk signalling
JAK/STAT signalling
HIF signalling
TGF-β signalling and general transcriptional control
5. Model organisms for studying BHD syndrome
Mouse models
Rat model
Dog model
Drosophila model
S. Pombe model
6. Future Work
Clinical research
Basic biology
Drugs and therapies
7. References
Resources
BHD Literature Database
BHD Article Library
Basic
Clinical
Laboratory Essentials
BHD Cell Lines
BHD Animal Models
BHD Mutation Databases
BHD Antibodies and Related Products
Clinical Trials
Funding
