Hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a naturally occurring canine kidney cancer syndrome, originally described in German shepherd dogs. The RCND locus was narrowed to a small region on canine chromosome 5 that overlapped FLCN (Lingaas et al, 2003). The authors described a histidine to arginine mutation in exon 7 of canine FLCN that segregated with the disease phenotype.

Further details: Lab essentials – BHD Animal Models

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