Finding out what other proteins Folliculin interacts with is a good way of finding out what it does.

At the moment, Folliculin is known to interact with seven different proteins:

• FNIP1 – is important for the correct development of certain immune system cells, and helps Folliculin control cell growth, autophagy and development;
• FNIP2 – helps Folliculin control cell growth, autophagy, apoptosis and development;
• PKP4 – controls cell adhesion and cell division;
• RPT4 – controls how a certain group of genes called rRNA genes are switched on;
• The Rag proteins – activate cell growth;
• ULK1 and GABARAP – activate autophagy.

 

 
Publication date: December 2014
Review date: December 2017