BHD Literature Database Updated

The literature data base has been updated with one paper:

Tsun et al. show that the GDP-bound form of RagC is required to recruit mTORC1 to lysosomes, where it is activated in response to amino acid stimulation. Furthermore, the authors show that during amino acid starvation, FNIP2 recruits Folliculin to the lysosome, where it interacts with the Rag proteins. Upon restimulation with amino acids, FLCN and FNIP2 act as a GTPase activating protein (GAP) towards RagC and RagD, facilitating the hydrolysis of GTP-bound RagC to GDP, and subsequently activating mTORC1 signalling.

To find out more, download the latest version of the database here.

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