BHD Literature Database Updated – crystal structure of Folliculin

The BHD Literature Database has been updated with a paper by Nookala et al. The authors presented the crystal structure of the C-terminal domain of Folliculin and identified that Folliculin is likely a member of the DENN domain protein family. Further biochemical assays demonstrated that Folliculin has guanine nucleotide exchange factor activity.

Nookala et al. is an important research milestone which will help to understand the cellular function of Folliculin and provide information for better drug targeting.

To find out more, download the latest version of the database here.

Nookala et al. is freely available to download in the BHD Article Library: Basic section.

 

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