Differential diagnosis of Cystic Lung Diseases

Cystic lung disease are classified by the presence of multiple, spherical or irregular shaped, thin walled, air filled spaces. Several conditions can cause such cysts and recently two reviews were published that discuss differential diagnosis based on clinical and radiographic feature.

Ha et al., 2015 provides the basis for a systematic, step wise diagnosis of LAM, BHD, pulmonary Langerhans cell histiocytosis, interstitial
pneumonia, congenital cystic lung disease, pulmonary
infection, and systemic disease. These conditions are discussed in terms of clinical presentation and characteristic radiographic features.

Gupta et al., 2015 is a more in depth, two-part review of the pathogenesis, pathology, diagnosis and management of a range of diffuse cystic lung diseases. Part I reviews cystic lung disease associated with neoplasm (including LAM and pulmonary Langerhans cell histiocytosis), infections, smoking related disease and interstitial lung disease. Part II reviews genetic mutations (focusing on BHD), aberrant lung development and lymphoproliferative disorders.

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